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World's First Baby Has Been Born From a Cancer Survivor's Frozen, Lab-Matured Egg

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At a world premiere, a woman who was spayed by cancer treatment gave birth after one of her 
immature eggs was matured, frozen and then, five years later, thawed and fertilized, 
researchers in France reported.

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A study published in the Annals of Oncology magazine published on Wednesday describes how 
the baby of a 34-year-old French woman who had been treated with breast cancer chemotherapy 
was born.

Before the start of treatment, doctors removed seven immature ovules from the ovaries and 
used a technique called in vitro maturation (IVM) to allow the ovules to develop further in 
the laboratory.

To date, there have been no successful pregnancies in patients with MIV cancer and egg 
freezing.However, some babies were born as a result of IVM immediately followed by 
fertilization and transfer to the patient.

Michael Grynberg, head of the Department of Reproductive Medicine and Fertility Conservation 
at the Antoine Beclere University Hospital, near Paris, said he learned of the 29-year-old 
patient's case.

"I offered him the opportunity to freeze the ovules after IVM and also to freeze the ovarian 
tissue," he said.

The patient rejected the second option because it was too invasive only a few days after 
the cancer diagnosis.

The so-called ovarian tissue cryopreservation is an experimental method in which the outer 
layer of an ovary, which contains immature ovules, is removed from the body and frozen for 
future use.




In the case of the French patient, the ultrasound revealed that there were 17 small bags 
filled with fluid containing immature ovules in her ovaries.

But the use of hormones to stimulate the ovaries to mature the ovules would have taken too 
long and could have made their cancer worse, leaving immature ovum recovery and freezing as 
the best option.

Less invasive IVF

"The preservation technique by freezing stimulation (hormonal) works less well, but in this 
case we really had no choice," Grynberg said on the AFP phone.

After five years, the patient recovered from breast cancer, but could not conceive naturally.
Chemotherapy had left her sterile.

After age 40, approximately 40 percent of breast cancer patients go through menopause due to
their treatment. At 30, the percentage is 15-20 percent.

Six of the eggs that had been frozen five years earlier survived the defrosting process and 
five were successfully fertilized.

One of these fertilized eggs was transferred to the patient's uterus and gave birth to a 
healthy baby named Jules on July 6, 2019.




"We have shown that this technique, although it can be improved, allows women in this 
situation to have children," Grynberg said.

Experts not involved in the procedure described it as an advance.

"The successful maturation of the ovules after ovarian removal was a challenge, so this is 
a positive positive step," said Richard Anderson, chief of obstetrics and gynecology at the 
MRC Center for Reproductive Health at the University of Edinburgh. .

Freezing the eggs at that stage also means that they remain the property of the woman, 
without the complications that a couple's sperm use can fertilize to fertilize, he said.

"This progress is particularly important for cancer patients, but it is also a step towards 
easier and less invasive in vitro (IVF) fertilization," Anderson added.
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